097 Identifying novel acoustic emission biomarkers for use in knee osteoarthritis clinical trials

Biomarkers in osteoarthritis: a clinical trials perspective

External Validity of Knee Osteoarthritis Clinical Trials: A Systematic Review

©2015 Turkish League Against Rheumatism. All rights reserved. Randomized trials are often used as key evidence for detecting the effectiveness of treatments in knee osteoarthritis (KOA).1-3 However, for these trials to be clinically useful, trial participants should have similar characteristics with patients shown in clinical practices. To achieve this, trials need to be evaluated in terms of e...

clinical trials and biomarkers in cmt

charcot-marie-tooth (cmt) diseases represent a heterogeneous genetic disorder with more than 80 genes implicated, however sharing a similar phenotype. in recent years, advances in molecular genetics and molecular biology, and also the development of various animal models of cmt, have led to a better understanding. this knowledge represents a prerequisite for the development of future therapies ...

Design Evaluation in Novel Orthoses for Patients with Medial Knee Osteoarthritis

Osteoarthritis of the knee is a debilitating condition affecting increasing numbers of individuals each year. One option for treatment is orthotic knee braces, but a little independent reviews have taken place to date on their relative outcomes for users. This study therefore evaluates the efficacy of different types of knee orthoses (braces) with regard to key aspects of use, including gait pa...

Biomarkers in Clinical Trials

In contemporary cardiovascular practice, the most common and useful applications of biomarkers focus on disease diagnosis, with troponins for myocardial infarction and natriuretic peptides for heart failure representing the most notable examples. Identification of additional cardiovascular diagnostic markers has proved challenging, however, because high quality studies for diagnostic indication...